UK scientists have developed a probe to monitor bicarbonate concentrations in mitochondria - components in living cells that generate chemical energy. Monitoring bicarbonate levels will improve researchers' understanding of its role in cellular reaction mechanisms.
A challenge when designing cellular probes is ensuring that the probe is not only selective for its target but can also be delivered to the site of interest within the cell. A team of scientists led by David Parker at the University of Durham has made a probe that can overcome this challenge.